This edition covers the main concepts and studies on the chemokine RANTES and its relationship to cavitation osteonecrosis, also known as: cavitations, FDOJ (fatty degenerative osteonecrosis of the jawbone), BMDJ (bone marrow disease of the jawbone), osteonecrotic cavitation-induced neuralgia. Aetiopathogenesis, morphology, diagnosis and systemic relationships as well as the basics of maxillomandibular osteoimmunology and understanding the healing and repair processes of bone and their relationship to metabolism.   Scientific principles necessary for the understanding of pathology in dentistry and medicine.     Pages: 400Language: French     Une toute nouvelle façon de voir la bouche et son impact sur les maladies systémiques. Des informations importantes sur les voies fonctionnelles et immunologiques entre la bouche et le corps Découvrez comment cibler, diagnostiquer et traiter cette maladie mortelle inconnue et silencieuse et découvrez une toute nouvelle facette de la dentisterie qui fera passer votre cabinet de dentiste à un centre de soins de santé de premier plan. Définitions et résultats scientifiques : Les maladies auto-immunes sont en forte augmentation dans le monde entier. Les scientifiques ne sont pas certains des causes de cette augmentation. Ce livre décrit les liens entre l'inflammation locale de la mâchoire et de nombreuses maladies graves et explique comment une simple intervention chirurgicale peut aider vos patients à retrouver leur vie, leur énergie et leur santé. Qu'est-ce que le NICO, le FDOJ et l'ostéo-immunologie maxillo-mandibulaire dans la dentisterie moderne ? Faits scientifiques : Le lien définitif entre l'inflammation locale dans l'os de la mâchoire et la maladie systémique - Comment les signaux immunitaires hyperactivés RANTES/CCL5 provenant de la bouche provoquent un déraillement systémique massif du système immunitaire. Comment et pourquoi la technologie joue un rôle majeur dans le diagnostic et le traitement de cette pathologie. Imagerie sans radiation de la densité osseuse par ultrasons et pourquoi la radiographie traditionnelle n'est pas suffisante pour la diagnostiquer. Comment utiliser la 3D-CBCT, les tests sanguins et l'échographie osseuse pour trouver l'origine de la pathologie afin d'accélérer le diagnostic et la planification du traitement dans le cadre d'une approche moins invasive pour cibler et traiter FDOJ avec une grande précision. Comment différencier un os sain d'un os enflammé avant de poser des implants pour obtenir de bien meilleurs résultats. Endodontie et CaviTAU® : Y a-t-il encore de l'inflammation après le traitement et la radiographie 2D est-elle suffisante pour être certain du succès ? Névralgie du trijumeau, douleur faciale et NICO : "Probablement la maladie la plus douloureuse au monde". Comment Jawbone Detox peut aider à traiter avec succès les causes de cette maladie, qui peut souvent conduire au suicide. La neurodégénérescence dans la sclérose latérale amyotrophique (SLA), la sclérose en plaques, la fibromyalgie, le syndrome de fatigue chronique et le lien entre RANTES/CCL5 provenant de défauts de la moelle osseuse (FDOJ) et le système nerveux central. Comment diagnostiquer et traiter facilement avec l'aide de la technologie des ultrasons et des protocoles Jawbone Detox.

Published by Dr. Dr. (PHD-UCN) Johann Lechner This comprehensive booklet provides valuable insights into Chronic Osteonecrosis and Fatty Degenerative Osteonecrosis in the Jawbone (COJ/FDOJ) through a series of visual documentation. The booklet features a collection of high-resolution images and corresponding X-rays that vividly showcase the severity and implications of osteonecrotic conditions. Dr. Lechner's expertise and meticulous documentation enable a deeper understanding of the relationship between chronic jawbone inflammation and various systemic diseases. Different Tumors Atypical Facial Pain/Trigeminal Neuralgia Rheumatic Complaints Internal Diseases Immune Diseases Neuropathic Diseases Chronic Fatigue Sydrome/Burn-Out To document the osteonecrotic intensity of the FDOJ cases the Corresponding individual X-rays are displayed beside/above the FDOJ images.

oklet” Digital transalveolar ultrasonography reveals undetected pathologies of the alveolar bone marrow. In 13 chapters, abstracts from 27 recognized scientific publications provide a comprehensive overview of the state of cytokine-based research using more than 200 image documents of excavated osteonecrotic jawbone marrow (FDOK)Language: English

“Booklet” Digital transalveolar ultrasonography reveals undetected pathologies of the jaw bone marrow. Publisher Dr.med.dent. Dr.(PhD-UCN) Johann Lechner In 13 chapters, abstracts from 27 recognized scientific publications demonstrate a comprehensive overview of the state of cytokine-based research on more than 200 image documents of excavated osteonecrotic jawbone marrow (FDOK).  Pages: 100  Language: German 

Edited by Dr. Dr. (PhD-UCN) Johann Lechner | Dr. Andres Fernandez | Dr. Fabian Schick | Dr. Florian NotterWith this bookknow the phenomenon of localized fatty degenerative osteonecrosis in the jawbone (FDOK cavitation).are able to assess the systemic-immunological effects of FDOJ cavitation.know why X-ray OPG and CBCT are not sufficient to objectify FDOK cavitation.learn the new ultrasound measurement of bone density with CaviTAU®use CaviTAU® to successfully assess the osteoimmunological situation around implants, under root-filled teeth and in operated jaw areas.learn the patient-oriented significance of the RANTES/CCL5 source in the jawbone from numerous case studies.shed light on the discussion about “NICO”/FDOK cavitation and “jaw ostitis” for your patients with completely radiation-free CaviTAU® ultrasoundPages: 456 Language: Spanish

From misjudged local inflammation to dangerous systemic disease.Dr. Dr. (PhD-UCN) Johann LechnerYou will gain insight into the functional and immunological derailment of the jawbone.You will learn the localisation of jawbone inflammation through new ultrasound sonography. Scientifically sound definition:What is NICO, FDOJ and Maxillo-Mandibular Osteoimmunology in modern dentistry? Scientific fact:The link from local inflammation to systemic dysfunction - hyperactivated immune signals RANTES/CCL5 from the jawbone. Unique in dental practice:Objective localisation of inflammation in the jawbone with the latest ultrasound technology CaviTAU®. CaviTAU® in the practice and in Slow Dentistry:Radiation-free imaging of bone density with ultrasound: bone density beyond X-rays. CaviTAU® shows jawbone with reduced bone density:Where are the systemic and immunologically relevant RANTES/CCL5 roots of disease? Implant success, Clean Implants and CaviTAU®:"Do I implant into healthy bone? Or into bone marrow defects?" Endodontics and CaviTAU®:Is there post-endodontic inflammation? Trigeminal neuralgia, facial pain and CaviTAU®:Probably the most painful disease in the world. Neurodegeneration ALS, MS and CaviTAU®:RANTES/CCL5 from bone marrow defects and CNS? 398 pages392 illustrations670 referencesLanguage: EnglishISBN: 978-3-931351-45-8

With these four books, the authors establish a new field in medicine and dentistry:An Interdisciplinary Maxillo-Mandibular Osteoimmunology. All four volumes document the fatty degenerative osteolyses of the jawbone on a case-by-case basis, emphasise their conspicuous overexpression of the inflammatory messenger RANTES/CCL5 and discuss chronic diseases possibly triggered by this on the basis of scientific publications in GoogleScholar.

Dr. Dr. (PhD-UCN) Johann LechnerVisualisation of cavity-forming osteolyses in the jawbone with sonographyRadiation-free imaging for maxillo-mandibular osteoimmunologyPathomechanisms of chronic inflammatory diseases With over 200 multicolour images for interpretation of CaviTAU® ultrasound measurements (www.cavitau.de/) on bone density in the jaws With over 560 literature citations on the scientific background ISBN 978-3-931351-43-4

Dr. Dr. (PhD-UCN) Johann LechnerMaxillo-mandibular osteoimmunology and chronic inflammation in the jawbone After Volume I in 2011, Volume II in 2015, Volume III on cavity-forming osteolyses of the jawbone with their oral and systemic manifestations will now be published in 2019. These three books by the authors Dr.Dr.(PhDUCN) J. Lechner, Prof. JE. Bouquot and Dr. V. von Baehr, with a total of over 600 colour illustrations and over 1,000 literature citations, establish the new therapeutic and research branch of a "Maxillo-Mandibular Osteoimmunology" on over 800 pages. ISBN 978-3-931351-35-9

Dr. Dr. (PhD-UCN) Johann LechnerOral and Systemic Manifestation of a Maxillo-Mandibular OsteoimmunologyWith this book, three authors enter a new field in medicine and dentistry: an interdisciplinary maxillo-mandibular osteo-immunology. They present this in a case-related and casuistic manner and discuss the clinical pictures associated with fatty degenerative osteolysis of the jawbone (FDOK). Following Volume I entitled "Cavity-forming osteolyses of the jawbone" from 2011, further scientific data on FDOK is now available. Prof. Bouquot has made available his extensive histological image material on FDOK / "NICO". In addition, 2000 of his own histologies from FDOK were analysed and evaluated. ISBN 978-3-931351-30-4  

Dr. Dr. (PhD-UCN) Johann LechnerSystematic-holistic effects of the aseptic osteonecroses "jaw ostitis" and "NICO" in the jawIn the author's practice, astounding improvements in rheumatoid, neuralgic complaints and other systemic diseases are observed after cleaning painless and radiographically inconspicuous edentulous jaw areas (NICO). These are structurally characterised by fatty-degenerative osteonecrosis of the cancellous bone. In order to clarify systemic relationships, osteolytic and fatty-degenerative cancellous bone portions were taken from jaw areas in a total of 17 subjects and analysed for 27 immune messengers using bead-based multiplex technology. All 17 NICO samples consistently showed the highest levels of RANTES/CCL5. The scientific literature on the causes and metastatic tendency of breast cancer assigns a key role to RANTES as a signalling agent.ISBN 978-3-931351-19-9

Beautifully designed book slipcase for the entire book series in German: Volumes I to IV "Cavity-forming osteolyses in the jawbone" by Dr. Dr. (PhD-UCN) Johann Lechner.

Dr. Dr. (PhD-UCN) Johann Lechner  Unknown and unrecognised dangers to health from tooth and jaw interference fields.The book "The Enemy in My Mouth" is a captivating account of a holistic treatment concept. It considers the organism as an interconnected overall system and takes into account both medical and dental aspects of a disease. The author realises this practice in a combination of 30 years of experience in holistic dentistry and a complementary activity as a non-medical practitioner.Many chronically ill people suffer from a clinical picture that they are not even aware of as such at the moment: chronic stress from the dental and jaw area. Everyone should know about what stresses or harms or can harm them so that they can protect and safeguard themselves.Only available in German!

Dr. Dr. (PhD-UCN) Johann Lechner  Alveolar Cavitations - Fatty-Degenerative Osteonecrosis of the Jawbone  The book Alveolar Cavitations describes fatty-degenerative osteonecrosis of the jawbone (FDOK)—a condition previously underestimated—as chronic aseptic and ischemic changes in the jawbone marrow, in which functional bone tissue is replaced by degenerated fatty tissue.  These lesions, which are difficult to detect on X-rays, are not simply a case of “poor wound healing,” but represent a distinct pathology with a specific morphological and immunological end-state. Osteoimmunological dysregulation between the bone and immune systems leads to characteristic patterns of cytokine expression, with singular overexpression of RANTES/CCL5. At the same time, the classic inflammatory markers TNF-α and IL-6 are significantly reduced. This constellation explains a “silent,” chronic inflammation without typical clinical Th1/Type 1 inflammatory signs and is discussed as a possible source of systemic immunological effects, for example in autoimmune, tumor, or neurodegenerative diseases.  The FDOK clearly distinguishes Alveolar Cavitations from drug-induced osteonecrosis of the jaw, classifies them under ICD-10 (M87.0/M87.2) and ICD-11 (FB81.0), and questions both blanket surgical interventions and biased rejections of this clinical picture. Modern, radiation-free imaging techniques such as transalveolar ultrasonography (TAU) are presented as a diagnostic adjunct and are becoming increasingly important in clinical practice. 

Dr. Dr. (PhD-UCN) Johann Lechner  “The Most Painful Disease in the World” – Trigeminal Neuralgia and Facial Pain The book “The Most Painful Disease in the World” – Trigeminal Neuralgia and Facial Pain explores the causes and treatment options for trigeminal neuralgia—one of the most painful conditions affecting the face. The focus is on the fact that this pain can also be caused by an often-overlooked, initially inconspicuous fatty-degenerative jawbone disease (FDOK/“NICO”).In the book, over 80 patients provide authentic accounts showing that conventional dental X-ray procedures often fail, leaving those affected without a clear diagnosis of FDOK/“NICO” for a long time. The complementary solution in all these cases is the unique CaviTAU® ultrasound diagnostic method (www.cavitau.de), which detects hidden, underlying FDOK/“NICO” inflammation in the jaw. A minor surgical correction of the harmful jaw defects provides relief for the patients in their medical histories. The book criticizes established practice, which often fails to recognize these inflammations in the jaw. Overall, the book advocates for expanded diagnostics in dentistry and oral surgery. This informative read offers those affected new perspectives and hope for relief from chronic facial and nerve pain.  Visitors seeking help can find a directory of ultrasound practitioners familiar with this treatment at www.cavitau.de. The author’s scientific paper on facial and nerve pain can be found at https://doi.org/10.1155/2015/582520Digital Object Identifier (DOI): Lechner J, von Baehr V. Peripheral Neuropathic Facial/Trigeminal Pain and RANTES/CCL5 in Jawbone Cavitation. Evid Based Complement Alternat Med. 2015;2015:582520. doi: /2015/

Dr. Dr. (PhD-UCN) Johann Lechner   Alveoläre Kavitäten -  fettig-degenerativen Osteonekrosen des Kieferknochens Das Buch Alveoläre Kavitäten beschreibt die bislang unterschätzten fettig-degenerativen Osteonekrosen des Kieferknochens (FDOK) als chronisch aseptische und ischämische Veränderungen des Kieferknochenmarks, bei denen funktionsfähiges Knochengewebe durch degeneriertes Fettgewebe ersetzt wird. Diese röntgenologisch schwer erkennbaren Läsionen sind nicht einfach nur eine „schlechte Wundheilung“, sondern stellen eine eigenständige Pathologie mit morphologischer und immunologischer Endstruktur dar. Osteoimmunologische Fehlregulationen zwischen Knochen- und Immunsystem führen zu charakteristischen Mustern von Zytokin Expressionen mit singulär überexprimierter Expression von RANTES/CCL5. Gleichzeitig sind die klassischen Entzündungsmarker TNF-α und IL-6 stark reduziert. Diese Konstellation erklärt eine „stille“, chronische Entzündung ohne typische klinische Th1/Typ1 Entzündungszeichen und wird als mögliche Quelle systemisch- immunologischer Wirkung diskutiert, etwa bei Autoimmun-, Tumor- oder neurodegenerativen Erkrankungen. Alveoläre Kavitäten grenzt FDOK klar von medikamentenassoziierten Kiefernekrosen ab, ordnet sie in ICD-10 (M87.0/M87.2) und ICD-11 (FB81.0) ein und hinterfragt sowohl pauschalisierte operative Eingriffe als auch voreingenommene Ablehnungen des Krankheitsbildes.Moderne, strahlungsfreie Bildgebungsverfahren wie die transalveoläre Ultraschallsonographie (TAU) werden als diagnostische Ergänzung vorgestellt und gewinnen in der Praxis immer mehr an Bedeutung.